Michael Winn ; Rebecca J. M. Goss ; Ken-ichi Kimura ; Timothy D. H. Bugg Nat Prod Rep 2010, 27 279-304 The quest for new antibiotics, especially those with activity against Gram-negative bacteria, is urgent; however, very few new antibiotics have been marketed in the last 40 years, with this limited number falling into only four new structural classes. … Read more
Amany E. Ragab ; Sabine Grüschow ; Emma J. Rackham ; Rebecca J. M. Goss Org Biomol Chem 2010, 8 3128-3129 Feeding phenylalanine analogues to Streptomyces coeruleorubidus reveals the remarkable steric and electronic flexibility of this biosynthetic pathway and leads to the generation of a series of new halopacidamycins.
Sabine Gruschow ; Emma J. Rackham ; Benjamin Elkins ; Philip L. A. Newilll ; Lionel M. Hill ; Rebecca J. M. Goss ChemBioChem 2009, 10 (2) 355-360 Pacidamycins, mureidomycins and napsamycins are structurally related uridyl peptide antibiotics that inhibit translocase I, an as yet clinically unexploited target. This potentially important bioactivity coupled to the biosynthetically intriguing … Read more
Abhijeet Deb Roy ; Rebecca J. M. Goss ; Gerd K. Wagner ; Michael Winn Chem Commun 2008, 4831-4833 A convenient and high yielding procedure for the Suzuki–Miyaura cross-coupling of unprotectedbromo- and chlorotryptophans in water provides fluorescent aryltryptophans.
Michael Winn ; Abhijeet Deb Roy ; Sabine Grüschow ; Raj S. Parameswaran ; Rebecca J. M. Goss Bioorg Med Chem Lett 2008, 18 (16) 4508-4510 A one-pot biotransformation for the generation of a series of l-aminotryptophans using a readily prepared protein extract containing tryptophan synthase is reported. The extract exhibits remarkable stability upon freeze-drying, and may … Read more
Rebecca J. M. Goss ; Philip L. A. Newill Chem Commun 2006, 4924-4925 A scalable and general biotransformation for the generation of a series of L-halotryptophans using the lysate of a commercially available microorganism containing tryptophan synthase.
Rebecca J. M. Goss ; Simon E. Lanceron ; Nicola J. Wise ; Steven J. Moss Org Biomol Chem 2006, 4, 4071-4073 We report a convenient synthesis of 4-fluorocyclohexanoic acid, and an insight into the rules governing acceptance of starter acid analogues in the precursor-directed biosynthesis of rapamycin.