Duncan Smith

Access to High Value Natural and Unnatural Products through Hyphenating Chemical Synthesis and Biosynthesis

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Access to natural products and their analogues is crucial. Such compounds have, for many years, played a central role in the area of drug discovery as well as in providing tools for chemical biology­. The ability to quickly and inexpensively acquire genome sequences has accelerated the field of natural product research. Access to genomic data … Read more

The First One-Pot Synthesis of l-7-Iodotryptophan from 7-Iodoindole and Serine, and an Improved Synthesis of Other l-7-Halotryptophans

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A simple and scalable one-pot biotransformation enables direct access to l-halotryptophans, including l-7-iodotryptophan, from the corresponding haloindoles. The biotransformation utilizes an easy to prepare bacterial cell lysate that may be stored as the lyophilizate for several months and utilized as a catalyst as and when required. Smith, DRM, Willemse T, Gkotsi DS, Schepens W, Maes BU, Ballet … Read more

Scope and potential of halogenases in biosynthetic applications

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Smith DRM; Grüschow S; Goss RJM Curr Opin Chem Biol 2012, 17 (2) 276-283 A large and diverse series of halogenated natural products exist. In many of these compounds the halogen is important to biological activity and bioavailability. We now recognise that nature has developed many different halogenation strategies for which well-known enzyme classes such as haem … Read more

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