Abhijeet Deb Roy

Gene Expression Enabling Synthetic Diversification of Natural Products : Chemogenetic Generation of Pacidamycin Analogs

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Abhijeet Deb Roy ; Sabine Grueschow ; Nickiwe Cairns ; Rebecca J. M. Goss JACS 2010, 132 (35) 12243-12245 Introduction of prnA, the halogenase gene from pyrrolnitrin biosynthesis, into Streptomyces coeruleorubidus resulted in efficient in situ chlorination of the uridyl peptide antibotic pacidamycin. The installed chlorine provided a selectably functionalizable handle enabling synthetic modification of the natural product using mild cross-coupling … Read more

An Expeditious Route to Fluorinated Rapamycin Analogues by Utilising Mutasynthesis

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Rebecca J. M. Goss ; Simon Lanceron ; Abhijeet Deb Roy ; Simon Sprague ; Mohammed Nur-e-Alam ; David L. Hughes ; Barrie Wilkinson ; Steven J. Moss ChemBioChem 2010, 11 (5) 698-702 Rapamycin is a drug with several important clinical uses. Its complex structure means that total synthesis of this natural product and its analogues … Read more

A convenient one-step synthesis of L-aminotryptophans and improved synthesis of 5-fluorotryptophan

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Michael Winn ; Abhijeet Deb Roy ; Sabine Grüschow ; Raj S. Parameswaran ; Rebecca J. M. Goss Bioorg Med Chem Lett 2008, 18 (16) 4508-4510 A one-pot biotransformation for the generation of a series of l-aminotryptophans using a readily prepared protein extract containing tryptophan synthase is reported. The extract exhibits remarkable stability upon freeze-drying, and may … Read more

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