Simon Lanceron

An Expeditious Route to Fluorinated Rapamycin Analogues by Utilising Mutasynthesis

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Rebecca J. M. Goss ; Simon Lanceron ; Abhijeet Deb Roy ; Simon Sprague ; Mohammed Nur-e-Alam ; David L. Hughes ; Barrie Wilkinson ; Steven J. Moss ChemBioChem 2010, 11 (5) 698-702 Rapamycin is a drug with several important clinical uses. Its complex structure means that total synthesis of this natural product and its analogues … Read more

Generating rapamycin analogues by directed biosynthesis: starter acid substrate specificity of mono-substituted cyclohexane carboxylic acids

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Rebecca J. M. Goss ; Simon E. Lanceron ; Nicola J. Wise ; Steven J. Moss Org Biomol Chem 2006, 4, 4071-4073 We report a convenient synthesis of 4-fluorocyclohexanoic acid, and an insight into the rules governing acceptance of starter acid analogues in the precursor-directed biosynthesis of rapamycin.  

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