Dan Tromans

Crystallization and preliminary X-ray analysis of Pac17 from the pacidamycin-biosynthetic cluster of Streptomyces coeruleorubidus

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Daniel R. Tromans ; Clare E. M. Stevenson ; Rebecca J. M. Goss ; David M. Lawson Acta Cryst 2012, F68 971-974 Pac17 is an uncharacterized protein from the pacidamycin gene cluster of the soil bacterium Streptomyces coeruleorubidus. It is implicated in the biosynthesis of the core diaminobutyric acid residue of the antibiotic, although its precise role is … Read more

Biogenesis of the Unique 4 ‘,5 ‘-Dehydronucleoside of the Uridyl Peptide Antibiotic Pacidamycin

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Amany E. Ragab ; Sabine Grüschow ; Daniel R. Tromans ; Rebecca J. M. Goss JACS 2011, 133 (39) 15288-15291 The pacidamycins belong to a class of antimicrobial nucleoside antibiotics that act by inhibiting the clinically unexploited target translocase I, a key enzyme in peptidoglycan assembly. As with other nucleoside antibiotics, the pacidamycin 4′,5′-dehydronucleoside portion is … Read more

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