Philip Newill – The Goss Lab

New Pacidamycin Antibiotics Through Precursor-Directed Biosynthesis

June 12, 2013 by Duncan Smith

Sabine Gruschow ; Emma J. Rackham ; Benjamin Elkins ; Philip L. A. Newilll ; Lionel M. Hill ; Rebecca J. M. Goss ChemBioChem 2009, 10 (2) 355-360 Pacidamycins, mureidomycins and napsamycins are structurally related uridyl peptide antibiotics that inhibit translocase I, an as yet clinically unexploited target. This potentially important bioactivity coupled to the biosynthetically intriguing … Read more

A convenient enzymatic synthesis of L-halotryptophans

June 12, 2013 by Duncan Smith

Rebecca J. M. Goss ; Philip L. A. Newill Chem Commun 2006, 4924-4925 A scalable and general biotransformation for the generation of a series of L-halotryptophans using the lysate of a commercially available microorganism containing tryptophan synthase.