* Denotes corresponding author
1. Halogenases: powerful tools for biocatalysis (mechanisms applications and scope)
DS Gkotsi, J Dhaliwal, MMW McLachlan, KR Mulholand, RJM Goss*
Current Opinion in Chemical Biology, 2018, 43, 119-126
2. Bromotryptophans and their incorporation in cyclic and bicyclic privileged peptides, 2018, Biopolymers, in press
3. Short and Sweet: Pac13 is a Small, Monomeric Dehydratase that Mediates the Formation of the 3′-Deoxy Nucleoside of Pacidamycin Antibiotics.
Freideriki Michailidou, Chun-wa Chung, Murray Brown, Andrew Bent, William Leavens, Sean Lynn, James H. Naismith and Rebecca J. M. Goss* Angewandte 2017, DOI 10.1002/ange.201705639
4. Living GenoChemetics: Hyphenating Synthetic Biology and Synthetic Chemistry in vivo
Sunil V. Sharma, Tong Xiaoxue, Cristina Pubill-Ulldemolins, Christopher Cartmell, Emma Bogosyan, Emma J. Rackham, Enrico Morelli, Refaat Hamed, & Rebecca J. M. Goss*
Nature Communications, 2017, DOI:10.1038/s41467-017-00194-3
5. Palladium –Catalysed a-Arylation of Ketones in Aqueous Media
V. Snieckus, C. N. Garcia-Irizarry, Y. Renault, S. V. Sharma, S. P. Nolan, E. Marelli and R. J. M. Goss, Synfacts, 2017, 13, 7, 0689
6. A translational synthetic biology platform for rapid access to gram-scale quantities of novel drug-like molecules.
James Reed, Michael J. Stephenson, Karel Miettinen, Bastiaan Brouwer, Aymeric Leveau, Paul Brett, Rebecca J.M. Goss, Alain Goossens, Maria A. O’Connell and Anne Osbourn*
Metabolic Engineering, 2017, 42, 185-193
7. Mild, aqueous α-arylation of ketones: toward new diversification tools for halogenated metabolites and drug molecules, Enrico Marelli*, Yohann Renault, Sunil V. Sharma, Steven P. Nolan and Rebecca J. M. Goss* Chemistry a European Journal, 2017, DOI:10.1002/chem.201700680
8. Discovery of a novel and unusual flavin‑dependent 5‑hydroxytryptophan halogenase from the metagenome of the marine sponge Theonella swinhoei, Duncan R. M. Smith, Agustinus R. Uria, Daniela Milbredt, Karl-Heinz van Pée, Jörn Piel*, Rebecca J. M. Goss* ACS Chemical Biology, 2017 in press
9. Sonogashira diversification of unprotected halotryptophans, halotryptophan containing tripeptides and a new to nature bromometabolite in water
M. J. Corr, S. Sharma, C. Pubill-Ulldemolins, R. T. Bown, P. Poirrot, D. R. M. Smith, C. Cartmell, T. Abou Fayad, R. J. M. Goss* Chem. Sci., 2017, DOI: 10.1039/C6SC04423A (Edge Article)
10. Contemprorary Catalysis: An introduction to biocatalysis (Book chapter for RSC Catalysis) , Ron Wever*, Rebecca J. M. Goss, Edward Spence, Xiaoxue Tong and A. F. Hartog, RSC publishing, 2017, in press
11. The Generation of New to Nature Natural Products Through Synthesis and Biosynthesis: Blending Synthetic Biology with Synthetic Chemistry (Book chapter for Chemical biology of Natural Products, editors: David Newman and Gordon Cragg), Chris Bailey, Emily Abraham and Rebecca J. M. Goss*, CRC publishing, 2017 in press
12. Contemprorary Catalysis: Biocatalysis (Book chapter for RSC Catalysis) Ron Wever*, M. J. Corr, Rebecca J. M. Goss, Paul Kamer, RSC publishing, 2017, in press
13. Bluegenics: bioactive natural products of medicinal relevance and approaches to their diversification, Joe Zarins Tutt, Emily Abraham and Rebecca J. M. Goss*, Prog. Mol. Biol.,Blue Biotechnology, 2017, 55, 159-186.
14. Rapid enzyme regeneration results in the striking catalytic longevity of an engineered, single species, biocatalytic biofilm. Xiaoxue Tong, Tania Triscari Barberi, Catherine H. Botting, Sunil V. Sharma, Mark J. H. Simmons, Tim W. Overton and Rebecca J. M. Goss* Microbial Cell Factories, 2016, 15, aritcle 180
15. One-pot access to l-5,6-dihalotryptophans and l-alknyltryptophans using tryptophan synthase, Michael Corr, Duncan Smith, Rebecca J. M. Goss*Tetrahedron, 2016, 72, 7306-7310.
16. Prospecting for new bacterial metabolites: a glossary of approaches for inducing, activating and upregulating the biosynthesis of bacterial cryptic or silent natural products.
J. Zarins Tutt, T. Triscari Barberi, H. Gao, A. Mearns-Spragg, L. Zhang, D. J. Newman and R. J. M. Goss* Nat. Prod. Rep., 2016, 33, 54-72
17. Promiscuous indolyl vinyl isonitrile synthases in the biogenesis of hapalindole-type alkaloids
Kuljira Ittiamornkul, Qin Zhu, Duncan Smith, Danai Gkotsi, Matthew L. Hillwig Nicole Nightingale, Rebecca J. M. Goss and Xinyu Li* Chem. Sci ., 2015, 6, 6836-6840
18. A One-Pot Synthesis of Symmetrical and Unsymmetrical Dipeptide Ureas
Fayad, D. Day and R. J. M. Goss,* EJOC, 2015, 25, 5603-5609
19. Suzuki–Miyaura Diversification of Amino Acids and Dipeptides in Aqueous Media
Tom Willemse, Karolien Van Imp, Rebecca J. M. Goss, Herman W. T. Van Vlijmen, Wim Schepens, Bert U. W. Maes* and Steven Ballet* Chem. Cat. Chem., 2015, 7, 2055-2070(back cover)
20. Simple and scalable access to L-7-halotryptophans and other L-halotryptophans through an improved one-pot biotransformation
Tom Willemse, Duncan R. M. Smith, Danai S. Gkotsi, Wim Schepens, Bert U. W. Maes, Steven Ballet, and Rebecca J. M. Goss J. Peptide Science, 2014, s143-s144
21. Filipins: the first antifungal “weed killers” identified from bacteria isolated from the trap-ant, H. Gao, S. Grüschow, M. Hutchings, D. Yu, and R. J. M. Goss* RSC Adv., 2014, 4, 57267 – 57270
22. A radical finding Nature Chemical Biology News&Views ,
R. J. M. Goss,* and S. Grüschow, Nature Chemical Biology News&Views, 2014, 10, 878–9.
23. Mechanism of Action of the Uridyl Peptide Antibiotics: An Unexpected Link to a Protein-Protein Interaction Site in Translocase MraY
Rodolis M. T., Mihalyi A., Ducho C., Gust B., Goss R. J. M., Van Lanen S., and Bugg T. D. H*, Chem. Comm. 2014, 50, 13023-5.
24. Science of Synthesis, Halogenases (book chapter)
Gruschow S, Smith D, Gkotski D., Goss R. J. M. Goss,* Science of Synthesis, 2014, 313-360
25. Simple and scale-able access to 7-halotryptophans, including L-7-iodotryptophan, through a one-pot biotransformation
D. Smith, S. Ballet, B. U. Maes, T. Willemse and R. J. M. Goss,* Orglett. 2014, 16, 10, 2622-2625
26. Access to High Value Natural and Unnatural Products through Hyphenating Chemical Synthesis and Biosynthesis
D. Smith, E. Bogosyan, K. Mahoney and R. J. M. Goss,* Synthesis, 2014, 46, 2122-2132.
27. Analysis and Optimisation of the Physiology of Engineered Biofilms for Biotransformations
J. T. Leech, I. Vizcaino-Caston, T. Barberi, R. J. M. Goss, M. Simmons, T. W. Overton
New Biotechnology, 2014, 31, S86
28. Edited Book: Natural Products: Discourse, Diversity and Design
E. Osbourn, G. Carter, and R. J. M. Goss,
Wiley-Blackwell, 2014, ISBN: 978-1-118-29806-0
29. Optimisation of engineered Escherichia coli biofilms for enzymatic biosynthesis of L-halotryptophans
S. Perni, L. Hackett, R. J. M. Goss, M. J. Simmons and T. W. Overton*
AMB Express, 2013, doi: 10.1016/j.cbpa.2013.01.018.
30. Scope and potential of halogenases in biosynthetic applications
D. R. Smith, S. Gruschow, R. J. M. Goss
Curr. Opin. Chem., Biol., 2013, 17, 276-283
31. Glycosyltransferases from oat (Avena) implicated in the acylation of avenacins.
Owatworakit, B. Townsend, T. Louveau, H Jenner, M. Rejzek, R. K. Hughes, G. Saalbach, X Qi, S Bakht, A. DebRoy, S. T. Mugford, R. J. M. Goss, R. A. Field, A. Osbourn
J. Biol. Chem., 2013, 288, 3696-3704.
32. Isolating antifungals from fungus-growing ant symbionts using genome guided chemistry
Ryan F. Sepke, S. Gruschow, R. J. M. Goss, and M. I. Hutchings*
Meth. Enzymol., 2012, 517, 47-70
33. Crystallization and preliminary X-ray analysis of Pac17 from the pacidamycin biosynthetic cluster of Streptomyces coeruleorubidus
Daniel R. Tromans, Clare E. M. Stevenson, Rebecca J. M. Goss and David M. Lawson*
Acta Crystallographica Section F., 2012, 68, 971-974
34. The Generation of “unNatural” Products, Combined Synthetic and Biosynthetic Approaches to Making Natural Product Analogues: Synthetic Biology Meets Synthetic Chemistry
R. J. M. Goss,* S. Shankar, and A. Abou Fayad,
Nat. Prod. Rep., 2012, 29, 870-889
35. Engineered Biofilms: a new Generation of Immobilised Biocatalysts
M. Winn, J. M. Foulkes, S. Peroni, M. H. Simmons,* T. W. Overton,* and R. J. M. Goss* Catal. Sci. and Technol., 2012, 2, 1544–1547,
36. Characterisation of Spin Coated Engineered Escherichia coli Biofilms using Atomic Force Microscopy A.N. Tsoligkas, J. Bowen, M. Winn, R. J. M. Goss, T. W. Overton, M. J. H. Simmons*,
Colloids Surf. B: Biointerfaces, 2012, 89:152-60.
37. Biogenesis of the Unique Nucleoside of the Uridyl Peptide Antibiotics: Pacidamycin
E. Ragab, S. Grüschow, R. J. M. Goss,*
J. Am. Chem. Soc., 2011, 133, 15288-91.
38. Diversity in natural product families is governed by more than enzyme promiscuity alone: establishing control of the pacidamycin portfolio
S. Grüschow, E. Rackham, R. J. M. Goss,*
Chem. Sci. 2011, 2, 2182-2186
Highlighted in Chemistry World http://www.rsc.org/chemistryworld/News/2011/August/11081101.asp
Highlight in C&EN News 89(34), August 22, 2011
RSC selected highlight of “cutting edge edge chemistry in 2011 http://www.rsc.org/chemistryworld/News/2011/December/chemistry-articles-most-exciting-events-2011.asp
39. A single Streptomyces mutualist makes multiple antifungals: a weedkiller cocktail used by the fungus farming ant Acromyrmex octospinosus ,
R. F. Seipke, J. Barke, C. Brearley, L. Hill, D. W. Yu, R. J. M. Goss, M. I. Hutchings*
PLoS ONE, 2011, 8, e22028
40. Pacidamycin, Cluster Identification and Heterologous Expression
E. Rackham, S. Gruschow, R. J. M. Goss*
Bioeng. Bugs, 2011, 2, 218-21.
41. Engineering Biofilms for Biocatalysis
A.N. Tsoligkas, M. Winn, J. Bowen, T. W. Overton, M. J. H. Simmons*, R. J. M. Goss*
ChemBioChem, 2011, 12, 1391-1395
42. Highlights from the 46th EUCHEM Conference on Stereochemistry, Burgenstock, Switzerland, May 2011
E. Tate and R. J. M. Goss
Commissioned review for Chem. Commun., 2011, 47, 10869-73
43. Saponins, Biogenesis and Medicinal Properties
A. E. Osbourn*, R. A. Field, M. O’Connell, R. J. M. Goss,
Nat. Prod. Rep., 2011, 28, 1261-8.
44. The total synthesis of chloptosin: A potent inducer of apoptosis in human pancreatic adenocarcinoma cell lines
A. J. Oelke, F. Antonietti, L. Bertone, D. J. France, R. J. M. Goss, T. Hofmann, S. Knauer, S. J. Moss, P. C. Skelton, R. M. Turner, G. Wuitschik, and S. V. Ley*
Chemistry – A European Journal , 2011, 17, 4183-94.
45. Gene expression enabling synthetic diversification of unnatural products:chemogenetic generation pacidamycin analogs
Deb Roy, S. Grüschow, N. Cairns, R. J. M. Goss*,
J. Am. Chem. Soc., 2010, 134, 1224-12245.
Highlighted in C.&EN. News, August 23rd, 2010.
46. Pacidamycin biosynthesis: Identification and heterologous expression of the first uridyl peptide antibiotic gene cluster
E. J. Rackham, S. Grüschow, A.E. Ragab, S. Dickens, and R. J. M. Goss*
ChemBioChem., 2010, 11, 1700-1709
47. Direct evidence for the use of multiple antifungals by a leaf-cutting ant.
J. Barke, R. F. Seipke, S. Grüschow, M. J. Bibb, R. J. M. Goss, D. W. Yu, and M. I. Hutchings*
BMC Biol., 2010, 8, 109
Labelled “Highly Accessed” http://www.biomedcentral.com/1741-7007/8/109
5400 downloads in the first month
48. New pacidamycins biosynthetically: probing N and C terminal substrate specificity of an unusual NRPS
A. E. Ragab, S Grüschow, E. J. Rackham, R. J. M. Goss,*
Org. Biomol. Chem., 2010, 8, 3128-3129
49. Fluororapamycins generated through the exploitation of biosynthesis,
R. J. M. Goss,* S. Lanceron, A. D. Roy, S. Spague, Nur-e-Alam, D. L. Hughes, B. Wilkinson, S. J. Moss
ChemBioChem., 2010, 11, 1439-4227
50. Antimicrobial nucleoside antibiotics targeting cell wall assembly: Recent advances in structure–function studies and nucleoside biosynthesis
M. Winn, R. J. M. Goss, K. Kimura and T. D. H. Bugg,*
Nat. Prod. Rep., 2010, 27, 279-304.
51. A serine carboxypeptidase-like acyltransferase is required for synthesis of antimicrobial compounds and disease resistance in oats
S. T. Mugford, X. Qi, S. Bakht, L. Hill, E. Wegel, R. K. Hughes, K. Papadopoulou, R. Melton, R. J. M. Goss, and A. E. Osbourn*
Plant Cell, 2009, 21, 2473-2484
52. New pacidamycin antibiotics through precursor-directed biosynthesis,
S. Grüschow, E. J. Rackham, B. Elkins, P. L. A. Newill, L. Hill, and R. J. M. Goss*
ChemBioChem., 2009, 10, 355-360
53. Pd mediated cross-coupling of unprotected halotryptophans in water,
Deb Roy, M. Winn, G. Wagner, and R. J. M. Goss,*
Chem. Commun., 2008, 39, 4831-4833
54. A convenient one-step synthesis of aminotryptophans and improved synthesis of halotryptophans,
M. Winn, A. Deb Roy, R. S. Parameswaran, and R. J. M. Goss*
Bioorg. Med. Chem. Let., 2008, 18, 4508-4510.
55. Rapamycin: requirement for hydroxylation of the cyclohexane ring of starter acids prior to incorporation,
R. J. M. Goss,* S. E. Lanceron, N. J. Wise, and S. J. Moss
Org. Biomol. Chem., 2006, 22, 4071-4073.
56. A convenient and environmentally friendly synthesis of L-halotryptophans,
R. J. M. Goss,* and P. L. A. Newill
Chem. Commun., 2006, 47, 4924-4925.
57. A novel fluorinated erythromycin antibiotic
R. J. M. Goss,* and H. Hong,
Chem. Commun., 2005, 31, 3983-3985.
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58. Elucidating and harnessing biosynthesis in order to extend the portfolio of fluorinated “natural” products
R. J. M. Goss*
ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY Volume: 243
Meeting Abstract: 16-Fluo Published: March 25th 2012
59. Elucidating and exploiting biosynthesis
R. J. M. Goss*
ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY Volume: 242
Meeting Abstract: 87-Biol Published: AUG 28 2011
60. New unnatural products by harnessing biosynthesis
R. J. M. Goss*
ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY Volume: 240
Meeting Abstract: 518-ORGN Published: AUG 22 2010
61. FLUO 13-Novel halogenated natural products from actinomycetes
R. J. M. Goss*
ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY Volume: 236 Meeting Abstract: 13-FLUO Published: AUG 17 2008
Papers From Postdoctoral training (2001-2003) and PhD (1997-2000)
62. Evidence that a Novel Thioesterase is Responsible for Polyketide Chain Release during Biosynthesis of the Polyether Ionophore Monensin
M. Harvey,M. A. Jones, Z. A. Hughes-Thomas, R. J. M. Goss, V. M. Bolanos-Garcia, W. Kroutil, J. Staunton, P. F. Leadlay, and J. B. Spencer*
Chembiochem., 2006, 7, 1435-1442.
63. Catalytically active tetra modular 6-deoxyethronolide B synthase fusion proteins.
C. M. Squire, R. J. M. Goss, H. Hong, P. F. Leadlay and J. Staunton,
Chembiochem., 2003, 4, 1225-1228.
64. An assay for the enantiomeric analysis of [2H1]-fluoroacetic acid: An insight into the stereochemical course of fluorination during fluorometabolite biosynthesis in Streptomyces cattleya.
D. O’Hagan , R. J. M. Goss, A. Meddour, and J. Courtieu,
J. Am. Chem. Soc, 2003, 125, 379-387.
65. Extreme enantiomeric discrimination of fluoroalkanes using deuterium NMR in liquid crystalline media.
M. Tavasli, J. Courtieu, R. J. M. Goss, A. Meddour, D. O’Hagan,
Chem. Commun., 2002, 8, 844-.
66. Biosynthesis of longianone from Xylaria longiana: a metabolite with a biosynthetic relationship to patulin.
R. J. M. Goss, J. Fuchser, and D. O’Hagan,
Chem. Commun., 1999, 22, 2255-2256.