Michael Winn

Characterisation of spin coated engineered Escherichia coli biofilms using atomic force microscopy

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Andreas N. Tsoligkas ; James Bowen ; Michael Winn ; Rebecca J. M. Goss ; Tim W. Overton ; Mark J. H. Simmons Colloids and Surfaces B: Biointerfaces 2012, 89 152-160 The ability of biofilms to withstand chemical and physical extremes gives them the potential to be developed as robust biocatalysts. Critical to this issue is their … Read more

Biofilms and their engineered counterparts: A new generation of immobilised biocatalysts

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Michael Winn ; Joanne M. Foulkes ; Stefano Perni ; Mark J. H. Simmons ; Tim W. Overton ; Rebecca J. M. Goss Cat Sci Tech 2012, 2 1544-1547 The robust nature of biofilms makes them medicinally difficult to treat, however this same property renders them an attractive method for protecting and immobilising enzymes for biotransformation. … Read more

Engineering Biofilms for Biocatalysis

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Andreas N. Tsoligkas ; Michael Winn ; James Bowen ; Tim W. Overton ; Mark J. H. Simmons ; Rebecca J. M. Goss ChemBioChem 2011, 12 (9) 1391-1395 Biofilm, friend not foe: Single species biofilms can be engineered to form robust biocatalysts with greater catalytic activity and significantly improved catalytic longevity than purified and immobilised enzymes. We … Read more

Antimicrobial nucleoside antibiotics targeting cell wall assembly: Recent advances in structure-function studies and nucleoside biosynthesis

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Michael Winn ; Rebecca J. M. Goss ; Ken-ichi Kimura ; Timothy D. H. Bugg Nat Prod Rep 2010, 27 279-304 The quest for new antibiotics, especially those with activity against Gram-negative bacteria, is urgent; however, very few new antibiotics have been marketed in the last 40 years, with this limited number falling into only four new structural classes. … Read more

A convenient one-step synthesis of L-aminotryptophans and improved synthesis of 5-fluorotryptophan

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Michael Winn ; Abhijeet Deb Roy ; Sabine Grüschow ; Raj S. Parameswaran ; Rebecca J. M. Goss Bioorg Med Chem Lett 2008, 18 (16) 4508-4510 A one-pot biotransformation for the generation of a series of l-aminotryptophans using a readily prepared protein extract containing tryptophan synthase is reported. The extract exhibits remarkable stability upon freeze-drying, and may … Read more

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