Generating rapamycin analogues by directed biosynthesis: starter acid substrate specificity of mono-substituted cyclohexane carboxylic acids

Rebecca J. M. Goss ; Simon E. Lanceron ; Nicola J. Wise ; Steven J. Moss Org Biomol Chem 2006, 4, 4071-4073 We report a convenient synthesis of 4-fluorocyclohexanoic acid, and an insight into the rules governing acceptance of starter acid analogues in the precursor-directed biosynthesis of rapamycin.