The Group’s research includes a diverse array of projects within the field of chemical biology, with natural products as the focus. The Group has a particular interest in understanding biosynthetic processes and the powerful combination of synthetic biology and organic chemistry to harness and redesign these systems, creating new biosynthetic pathways. The Group is interested in the manipulation of individual enzymes and biosynthetic pathways as a expeditious tool for synthesising designer ‘natural’ product analogues of medicinal value. The rapid access to libraries of natural products that biosynthetic manipulation can afford is useful for gaining a greater understanding of the exact molecular mode of action of drug molecules.
The Group focuses on understanding biosynthetic processes at the molecular level, and combining the tools of ogranic synthesis, molecular biology, and protein biochemistry to generate new natural products of our own design. Our research has been recognised through several prestigious awards.
The Group’s research can be broadly categorised into five overarching themes:
- Harnessing biosynthesis to access libraries of natural product analogues as tools for chemical biology
- Functionalising biomolecules
- Developing biotransformations for organic synthesis
- Discovery of new bioactive natural products
- Biosynthetic elucidation of unusual natural products