Category Archives: Sabine Grüschow

A convenient one-step synthesis of L-aminotryptophans and improved synthesis of 5-fluorotryptophan

Michael Winn ; Abhijeet Deb Roy ; Sabine Grüschow ; Raj S. Parameswaran ; Rebecca J. M. Goss

Bioorg Med Chem Lett 2008, 18 (16) 4508-4510

A one-pot biotransformation for the generation of a series of l-aminotryptophans using a readily prepared protein extract containing tryptophan synthase is reported. The extract exhibits remarkable stability upon freeze-drying, and may be stored and used for long periods after its preparation without significant loss of activity.