Publications

A mixed community of actinomycetes produce multiple antibiotics for the fungus farming ant Acromyrmex octospinosus

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Joerg Barke ; Ryan F. Seipke ; Sabine Grueschow ; Darren Heavens ; Nizar Drou ; Mervyn J. Bibb ; Rebecca J. M. Goss ; Douglas W. Yu ; Matthew I. Hutchings BMC Biology 2010, 8 109 ttine ants live in an intensely studied tripartite mutualism with the fungus Leucoagaricus gongylophorus, which provides food to the ants, and … Read more

Pacidamycin Biosynthesis : Identification and Heterologous Expression of the First Uridyl Peptide Antibiotic Gene Cluster

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Emma J. Rackham ; Sabine Grüschow ; Amany E. Ragab ; Shilo Dickens ; Rebecca J. M. Goss ChemBioChem 2010, 11 (12) 1700-1709 The pacidamycins are antimicrobial nucleoside antibiotics produced by Streptomyces coeruleorubidus that inhibit translocase I, an essential bacterial enzyme yet to be clinically targeted. The novel pacidamycin scaffold is composed of a pseudopeptide backbone linked by … Read more

An Expeditious Route to Fluorinated Rapamycin Analogues by Utilising Mutasynthesis

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Rebecca J. M. Goss ; Simon Lanceron ; Abhijeet Deb Roy ; Simon Sprague ; Mohammed Nur-e-Alam ; David L. Hughes ; Barrie Wilkinson ; Steven J. Moss ChemBioChem 2010, 11 (5) 698-702 Rapamycin is a drug with several important clinical uses. Its complex structure means that total synthesis of this natural product and its analogues … Read more

Antimicrobial nucleoside antibiotics targeting cell wall assembly: Recent advances in structure-function studies and nucleoside biosynthesis

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Michael Winn ; Rebecca J. M. Goss ; Ken-ichi Kimura ; Timothy D. H. Bugg Nat Prod Rep 2010, 27 279-304 The quest for new antibiotics, especially those with activity against Gram-negative bacteria, is urgent; however, very few new antibiotics have been marketed in the last 40 years, with this limited number falling into only four new structural classes. … Read more

New pacidamycins biosynthetically: probing N- and C-terminal substrate specificity

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Amany E. Ragab ; Sabine Grüschow ; Emma J. Rackham ; Rebecca J. M. Goss Org Biomol Chem 2010, 8 3128-3129 Feeding phenylalanine analogues to Streptomyces coeruleorubidus reveals the remarkable steric and electronic flexibility of this biosynthetic pathway and leads to the generation of a series of new halopacidamycins.

A Serine Carboxypeptidase-Like Acyltransferase Is Required for Synthesis of Antimicrobial Compounds and Disease Resistance in Oats

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Sam T. Mugford ; Xiaoquan Qi ; Saleha Bakht ; Lionel Hill ; Eva Wegel ; Richard K. Hughes ; Kalliopi Papadopoulou ; Rachel Melton ; Mark Philo ; Frank Sainsbury ; George P. Lomonossoff ; Abhijeet Deb Roy ; Rebecca J. M. Goss ; Anne Osbourn The Plant Cell 2009, 21 (8) 2473-2484 Serine carboxypeptidase-like (SCPL) … Read more

New Pacidamycin Antibiotics Through Precursor-Directed Biosynthesis

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Sabine Gruschow ; Emma J. Rackham ; Benjamin Elkins ; Philip L. A. Newilll ; Lionel M. Hill ; Rebecca J. M. Goss ChemBioChem 2009, 10 (2) 355-360 Pacidamycins, mureidomycins and napsamycins are structurally related uridyl peptide antibiotics that inhibit translocase I, an as yet clinically unexploited target. This potentially important bioactivity coupled to the biosynthetically intriguing … Read more

A convenient one-step synthesis of L-aminotryptophans and improved synthesis of 5-fluorotryptophan

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Michael Winn ; Abhijeet Deb Roy ; Sabine Grüschow ; Raj S. Parameswaran ; Rebecca J. M. Goss Bioorg Med Chem Lett 2008, 18 (16) 4508-4510 A one-pot biotransformation for the generation of a series of l-aminotryptophans using a readily prepared protein extract containing tryptophan synthase is reported. The extract exhibits remarkable stability upon freeze-drying, and may … Read more

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