I am a PhD student with a background in molecular biology/bioinformatics and a research focus on discovering and developing enzymes, particularly halogenases, as tools for synthesis. Through my studies I am gaining expertise in molecular biology, enzymology, biocatalysis, analysis and assay design.
A simple and scalable one-pot biotransformation enables direct access to l-halotryptophans, including l-7-iodotryptophan, from the corresponding haloindoles. The biotransformation utilizes an easy to prepare bacterial cell lysate that may be stored as the lyophilizate for several months and utilized as a catalyst as and when required.
Smith, DRM, Willemse T, Gkotsi DS, Schepens W, Maes BU, Ballet S, Goss RJM