I am a bioorganic chemist/chemical biologist with research interests in the biosynthesis of natural products at the chemical and genetic level. Specifically, my research focuses on natural products with important medicinal properties and in understanding how biosynthetically intriguing motifs within these compounds are assembled. From this vantage point we harness individual enzymes as convenient tools for organic synthesis, and employ a combination of synthetic chemistry and synthetic biology to harness entire biosynthetic pathways in order to enable expeditious access to libraries of medicinally relevant compounds. These libraries may be used to gain a greater understanding as to how the drug acts at the molecular level within the cell. I am establishing a national and international reputation presenting numerous invited research seminars across the world including Brazil, Capetown, Delhi, Kyoto, Denver and, Boston, in addition to invited seminars at numerous European departments and companies.
I am a highly motivated BioOrganic Medicinal Chemist with research interests in the synthesis,
biosynthesis and biosynthetic manipulation of natural products. Through my MSc I have developed skills in organic synthesis and I have extended these skills in biochemistry further through my PhD. I have a deep interest in the medical research field especially in the discovery and isolation of antibiotics. I am interested in how biosynthetic pathways may be harnessed in order to create natural products of my own design with improved biological. Combining synthetic chemistry and biosynthesis provides expeditious access to series of otherwise synthetically intractable natural product analogues. These libraries may be used to gain a greater understanding of the drug’s structure activity relationships.
I am a Molecular Microbiologist with research interests in the development of whole cell catalysts, with particular focus on engineering microbial biofilms as platform for biotransformations. Biofilms are known for their robustness and ability to withstand harsh environmental conditions, therefore I am working toward harnessing these features to develop a biocatalytic biofilm platform in which enzymes of choice are produced, enabling me to carry out biotransformations in continuous flow systems.
I am a PhD student with a background in molecular biology/bioinformatics and a research focus on discovering and developing enzymes, particularly halogenases, as tools for synthesis. Through my studies I am gaining expertise in molecular biology, enzymology, biocatalysis, analysis and assay design.
I am an organic/bioorganic chemist with research interests in the synthesis and biosynthesis of natural products. My previous work has included the synthesis and isolation of highly reactive superelectrophile compounds and the synthesis of fluorinated derivatives of natural products. My current research focuses on marrying biosynthesis and synthetic chemistry to generate new natural product analogues.
My research work focused on the natural products chemistry, including the isolation and structure determination of new bioactive natural, genome mining, and genetic manipulation of bioactive natural product biosynthesis. I have developed skills in the isolation and purification, structure elucidation, organic synthesis of natural products through my MSc and PhD. After that, my research centres on the screening of new antibiotics with the activity against drug-resistant-pathogens, particularly against tuberculosis, discovering new antibiotics from marine derived microbes, especially water-soluble antibiotics. As the traditional process of discovering new bioactive natural products is generally long and laborious, I am interested in the methodology of dereplication of microbial natural products by combing chemical LC-UV-MS and bioinformatics methods. In addition, I have a deep interest in the genetics and genetic manipulation of bioactive natural product biosynthesis.
I am a synthetic chemist/ chemical biologist with a particular interest in the biosynthesis of natural products, and am especially fascinated by the enzymes involved in in sugar and nucleoside biosynthesis and modification. I am passionate about biocatalysis, considering it the most striking and environmentally-friendly approach to synthesis. I am currently working on a very interdisciplinary project, combining synthetic chemistry, molecular biology and enzymology. Specifically, I am investigating the biosynthesis of the nucleoside moiety of pacidamycins, by focusing on the enzymes involved. Combining synthetic chemistry and heterologous expression, kinetic and crystallisation studies I aim to obtain a better understanding of the function of these enzymes, that could be potentially used for the generation of nucleoside antiviral targets.
I am a highly motivated organic/computational chemist with a particular interest in the synthesis and biosynthesis of natural products. With an interdisciplinary PhD in organic and computational chemistry and a MSc in Catalysis, I have valuable experience in designing, modelling and understanding organocatalytic and metal mediated catalytic transformations. In addition, I gained solid knowledge of organic synthesis through working on the synthesis of compounds with biological activity while holding a postdoctoral position at the Institute of Transformative Bio-Molecules (ITbM, Japan). Within the multidisciplinary Goss group, my current research focuses on the development of mild and aqueous methodologies in the context of new natural product analogue generation.
Allomerus ants ensure that they have sufficient nitrogen in their diet by trapping and consuming other insects. In order to construct their traps, like the more extensively studied leaf cutter ants, they employ fungal farming. Pest management within these fungal cultures has been speculated to be due to the ants’ usage of actinomycetes capable of producing antifungal compounds, analogous to the leafcutter ant mutualism. Here we report the first identification of a series of antifungal compounds, the filipins, and their associated biosynthetic genes isolated from a bacterium associated with this system.
Gao H, Grüschow S, Barke J, Seipke RF, Hill LM, Orivel K, Yu DW, Hutchings M, Goss RJM
A new family of radical halogenases has been discovered that regio- and stereoselectively chlorinates the unactivated carbon center of indolemonoterpenoid substrates without the prerequisite for the substrate to be bound to a protein carrier.
Goss RJM, Grüschow S